Variation aware analysis of bridging fault testing

This paper investigates the impact of process variation on test quality with regard to resistive bridging faults. The input logic threshold voltage and gate drive strength parameters are analyzed regarding their process variation induced influence on test quality. The impact of process variation on test quality is studied in terms of test escapes and measured by a robustness metric. It is shown that some bridges are sensitive to process variation in terms of logic behavior, but such variation does not necessarily compromise test quality if the test has high robustness. Experimental results of Monte-Carlo simulation based on recent process variation statistics are presented for ISCAS85 and -89 benchmark circuits, using a 45nm gate library and realistic bridges. The results show that tests generated without consideration of process variation are inadequate in terms of test quality, particularly for small test sets. On the other hand, larger test sets detect more of the logic faults introduced by process variation and have higher test quality

Dynamic Voltage Scaling Aware Delay Fault Testing

The application of Dynamic Voltage Scaling (DVS) to reduce energy consumption may have a detrimental impact on the quality of manufacturing tests employed to detect permanent faults. This paper analyses the influence of different voltage/frequency settings on fault detection within a DVS application. In particular, the effect of supply voltage on different types of delay faults is considered. This paper presents a study of these problems with simulation results. We have demonstrated that the test application time increases as we reduce the test voltage. We have also shown that for newer technologies we do not have to go to very low voltage levels for delay fault testing. We conclude that it is necessary to test at more than one operating voltage and that the lowest operating voltage does not necessarily give the best fault cover

Bridging fault test method with adaptive power management awareness

A key design constraint of circuits used in handheld devices is the power consumption, mainly due to battery life limitations. Adaptive power management (APM) techniques aim to increase the battery life of such devices by adjusting the supply voltage and operating frequency, and thus the power consumption, according to the workload. Testing for resistive bridging defects in APM-enabled designs raises a number of challenges due to their complex analog behavior. Testing at more than one supply voltage setting can be employed to improve defect coverage in such systems, however, switching between several supply voltage settings has a detrimental impact on the overall cost of test. This paper proposes a multi-Vdd automatic test generation method which delivers 100% resistive bridging defect coverage and also a way of reducing the number of supply voltage settings required during test through test point insertion. The proposed techniques have been experimentally validated using a number of benchmark circuits

EFFECTS OF MECHANICALLY GENERATED SLASH PARTICLE SIZE ON PRESCRIBED FIRE BEHAVIOR AND SUBSEQUENT VEGETATION EFFECTS

Forest managers have begun to restore ecosystem structure and function in fire-prone ecosystems that have experienced fire exclusion, commodity based resource extraction, and extensive grazing during much of the 20th century. Mechanical thinning and prescribed burning are the primary tools for thinning dense stands and restoring pre-settlement forest structure, reducing the likelihood of devastating crown fires. Mechanical thinning can be costly when trees are nonmerchantable and prescribed burning can be risky unless fuel loadings are first reduced. Furthermore, stands that remain dense after commercial thinning can produce undesirable wildland fire- or even prescribed fire- effects on vegetation and soils. Land managers are interested in using mastication equipment (Fig. 1) for thinning nonmerchantable trees as a means of restoring structure and function to dry forest ecosystems. However, it is unknown how the addition of mechanically derived slash influences potential fire behavior and fire effects. The objectives of this project were to test the effectiveness of mastication effort (defined as time needed to break fuels into smaller pieces) to 1) thin dense stands of dry coniferous forest within historically frequent, low-severity fire regimes (Fig. 1) and 2) create surface fuel beds that produce prescribed fire behavior with positive effects on residual trees, understory vegetation, and soils. Specifically, we asked the following questions: (1) How does slash particle size and fuel bed depth affect fire intensity and severity? (2) How do different mastication efforts and subsequent prescribed fire affect overstory vegetation? (3) Does soil heating change from burning different types of masticated slash? and (4) What are the differences in production costs among levels of mastication effort

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Although 5HT2A receptors mediate contractions of normal arteries to serotonin (5HT), in some cardiovascular diseases, other receptor subtypes contribute to the marked increase in serotonin contractions. We hypothesized that enhanced contractions of arteries from diabetics to 5HT are mediated by an increased contribution from multiple 5HT receptor subtypes. We compared responses to selective 5HT receptor agonists and expression of 5HT receptor isoforms (5HT1B, 5HT2A, and 5HT2B) in aorta from nondiabetic (ND) compared to type 2 diabetic mice (DB, BKS.Cg-Dock7m+/+Leprdb/J). 5HT, 5HT2A (TCB2 and BRL54443), and 5HT2B (norfenfluramine and BW723C86) receptor agonists produced concentration-dependent contractions of ND arteries that were markedly increased in DB arteries. Neither ND nor DB arteries contracted to a 5HT1B receptor agonist. MDL11939, a 5HT2A receptor antagonist, and LY272015, a 5HT2B receptor antagonist, reduced contractions of arteries from DB to 5HT more than ND. Expression of 5HT1B, 5HT2A, and 5HT2B receptor subtypes was similar in ND and DB. Inhibition of rho kinase decreased contractions to 5HT and 5HT2A and 5HT2B receptor agonists in ND and DB. We conclude that in contrast to other cardiovascular diseases, enhanced contraction of arteries from diabetics to 5HT is not due to a change in expression of multiple 5HT receptor subtypes

Lobeline attenuates d-methamphetamine self-administration in rats

ABSTRACT ␣-Lobeline inhibits d-amphetamine-evoked dopamine release from striatal slices in vitro, appearing to reduce the cytosolic pool of dopamine available for reverse transport by the dopamine transporter. Based on this neurochemical mechanism of action, the present study determined if lobeline decreases d-methamphetamine self-administration. Rats were surgically implanted with jugular catheters and were trained to lever press on a fixed ratio 5 schedule for intravenous d-methamphetamine (0.05 mg/kg/infusion). To assess the specificity of the effect of lobeline, another group of rats was trained to lever press on a fixed ratio 5 schedule for sucrose reinforcement. Pretreatment of rats with lobeline (0.3-3.0 mg/kg, 15 min prior to the session) decreased responding for both d-methamphetamine and sucrose reinforcement. Following repeated lobeline (3.0 mg/kg) administration, tolerance developed to the decrease in responding for sucrose; however, the lobeline-induced decrease in responding for d-methamphetamine persisted. Furthermore, the lobeline-induced decrease in responding for d-methamphetamine was not surmounted by increasing the unit dose of d-methamphetamine. These results suggest that lobeline produces a nonspecific rate suppressant effect following acute administration, to which tolerance develops following repeated administration. Importantly, the results also suggest that repeated administration of lobeline specifically decreases responding for d-methamphetamine in a noncompetitive manner. Thus, lobeline may be an effective, novel pharmacotherapy for d-methamphetamine abuse

A Metabolomic Endotype of Bioenergetic Dysfunction Predicts Mortality in Critically Ill Patients with Acute Respiratory Failure

Acute respiratory failure (ARF) requiring mechanical ventilation, a complicating factor in sepsis and other disorders, is associated with high morbidity and mortality. Despite its severity and prevalence, treatment options are limited. In light of accumulating evidence that mitochondrial abnormalities are common in ARF, here we applied broad spectrum quantitative and semiquantitative metabolomic analyses of serum from ARF patients to detect bioenergetic dysfunction and determine its association with survival. Plasma samples from surviving and non-surviving patients (N = 15/group) were taken at day 1 and day 3 after admission to the medical intensive care unit and, in survivors, at hospital discharge. Significant differences between survivors and non-survivors (ANOVA, 5% FDR) include bioenergetically relevant intermediates of redox cofactors nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP), increased acyl-carnitines, bile acids, and decreased acyl-glycerophosphocholines. Many metabolites associated with poor outcomes are substrates of NAD(P)-dependent enzymatic processes, while alterations in NAD cofactors rely on bioavailability of dietary B-vitamins thiamine, riboflavin and pyridoxine. Changes in the efficiency of the nicotinamide-derived cofactors\u27 biosynthetic pathways also associate with alterations in glutathione-dependent drug metabolism characterized by substantial differences observed in the acetaminophen metabolome. Based on these findings, a four-feature model developed with semi-quantitative and quantitative metabolomic results predicted patient outcomes with high accuracy (AUROC = 0.91). Collectively, this metabolomic endotype points to a close association between mitochondrial and bioenergetic dysfunction and mortality in human ARF, thus pointing to new pharmacologic targets to reduce mortality in this condition